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class="glidjfkvjou" id="sub_news"><h1>米鉑凍干粉針劑及其制備方法</h1><div class="glidjfkvjou" id="Context"><div id="glidjfkvjou" class="info">發布時間:2025-04-28</div><p><p><b>專利名稱</b>：米鉑凍干粉針劑及其制備方法<br> <b>技術領域</b>：<br>本發明涉及的是一種米鉬凍干粉針劑及其制備方法，屬于藥物技術領域。 <br> <b>背景技術</b>：<br>脂溶性鉬類金屬絡合物米鉬，化學名為順[((1R，2R)-1，2-環己二胺-N，N) 二 (十四烷酰氧基)]合鉬(II)及其水合物，結構式如下<br> <b>權利要求</b><br> 1.米鉬凍干粉針劑，含有米鉬，其特征在于，所說的米鉬凍干粉針劑在配制過程中使用叔丁醇和無水乙醇的混合溶劑，其中混合溶劑中叔丁醇的含量占溶劑總體積的97% 99%， 無水乙醇的含量占溶劑總體積的1% 3%。<br> 2.根據權利要求1所述的米鉬凍干粉針劑，其特征在于，所說的凍干粉針劑在配制過程，米鉬在混合溶劑的濃度為3. 93mg/ml。<br> 3.根據權利要求1所述的米鉬凍干粉針劑，其特征在于，所說的凍干粉針劑在配制過程，所說的混合溶劑中叔丁醇的含量占溶劑總體積的98%，無水乙醇的含量占溶劑總體積的 2%。<br> 4.米鉬凍干粉針劑的制備方法，其特征在于，其制備過程為將叔丁醇，加入至配料罐中，溶液溫度控制在3(T35°C，再稱取處方量的米鉬，在溫度下攪拌或超聲使之溶解均勻，然后量取處方量的無水乙醇，加入至配料罐中，攪拌均勻后將溶液溫度維持在2(T25°C，中間體檢查合格后，在無菌條件下，用0. 22Mffl的有機微孔濾膜過濾至澄明，按中間體計算所得裝量灌裝于西林瓶中，半塞上丁基橡膠塞，裝盤，送入凍干機，關閉箱門，開啟凍干機進行凍干，之后壓塞、出箱，用鋁塑組合蓋軋口，經質檢合格后包裝，即得。<br> <b>全文摘要</b><br> 本發明提供了一種米鉑凍干粉針劑及其制備方法，所說的米鉑凍干粉針劑含有米鉑，所說的米鉑凍干粉劑在配制過程中使用叔丁醇和無水乙醇的混合溶劑。本發明的凍干粉針劑在配制過程中使用無水乙醇，可以降低米鉑粉針劑對生產環境的溫度要求，保證米鉑溶液在生產過程中于室溫環境下不發生凝固或局部凝固；同時凍干成品中心粒徑分布為10~25μm，混懸在碘化油注射液中后24小時內沉降系數及黏度均無明顯變化，即所生產的樣品臨床使用時較穩定；本發明的米鉑凍干粉針劑的制備方法，能夠有效地防止溶液在生產過程中發生凝固或局部凝固，降低了生產成本，所得的米鉑凍干粉針劑有關物質含量低、質量穩定。<br> <b>文檔編號</b>A61K31/282GK102266297SQ201110201119<br> <b>公開日</b>2011年12月7日 申請日期2011年7月19日 優先權日2011年7月19日<br> <b>發明者</b>宗在偉, 楊奇珍, 趙俊 申請人:江蘇奧賽康藥業股份有限公司<br></p></p><div id="glidjfkvjou" class="like"><h3>產品知識</h3></div><div id="glidjfkvjou" class="like" style="margin-left:30px;"><h3>行業新聞</h3></div><div id="glidjfkvjou" class="artbtom"><ul><li><div id="glidjfkvjou" class="hotComments-recent-title"><div id="glidjfkvjou" class="sdhssh4s"><a href="http://www.sb2005.com/news/1746260438.html">一種休閑移動輸液架的制作方法</a></div><span>一種休閑移動輸液架的制作方法【專利摘要】本實用新型公開一種休閑移動輸液架，包括架體、扶手、具有鎖定功能的萬向輪、座位支架、座板、轉軸、背板和活動支架，其特征在于，所述架體底部固定連接有前腿支架和后腿支架，架體頂部與活動支架活動連接，架體正面</span></div></li><li><div id="glidjfkvjou" class="hotComments-recent-title"><div 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href="http://www.sb2005.com/news/1746315238.html">家用式無創血糖檢測儀的制作方法</a></div><span>家用式無創血糖檢測儀的制作方法【專利摘要】本實用新型涉及一種家用式無創血糖檢測儀，主要包括主機、指套和顯示屏三部分以及指紋識別模塊和袖帶，所述的檢測儀設計合理，高度整合了各個功能模塊，方便用戶隨時監測血糖，并能夠根據指紋識別和記錄不同用戶的</span></div></li><li><div id="glidjfkvjou" class="hotComments-recent-title"><div id="glidjfkvjou" class="sdhssh4s"><a href="http://www.sb2005.com/news/1746316390.html">一種設有防側漏抗菌面層的衛生巾的制作方法</a></div><span>一種設有防側漏抗菌面層的衛生巾的制作方法【專利摘要】一種設有防側漏抗菌面層的衛生巾，包括面層、吸收芯體和底膜，其特征在于所述面層由雙層抗菌無紡布構成，在所述下層抗菌無紡布的表面均勻分布著圓柱形凸起，凸起的高度從四周到中心逐漸減小，所述上層抗</span></div></li><li><div id="glidjfkvjou" class="hotComments-recent-title"><div id="glidjfkvjou" class="sdhssh4s"><a href="http://www.sb2005.com/news/1746316639.html">一種治療小兒頑固性咳喘的熨劑藥物的制作方法</a></div><span>專利名稱：一種治療小兒頑固性咳喘的熨劑藥物的制作方法技術領域：本發明涉及一種中藥制劑，即治療小兒頑固性咳喘效果十分理想的一種治療小兒頑固性咳喘的樊 劑藥物。背景技術：咳喘是一種呼吸系統常見疾病。引起的原因很多，除呼吸系統各器官，其它內臟的神</span></div></li><li><div id="glidjfkvjou" class="hotComments-recent-title"><div id="glidjfkvjou" class="sdhssh4s"><a href="http://www.sb2005.com/news/1746317818.html">聚酯增強可降解多孔硅酸鈣復合支架材料、制備及用途的制作方法</a></div><span>專利名稱：：聚酯增強可降解多孔硅酸鈣復合支架材料、制備及用途的制作方法技術領域：：本發明涉及生物材料領域，尤其涉及一種聚酯增強可降解生物活性多孔硅酸鉤復合支架材料、制備方法及其用途。背景技術：：一種良好的硬組織修復和替換材料，必須同時具備良</span></div></li><li><div id="glidjfkvjou" class="hotComments-recent-title"><div id="glidjfkvjou" class="sdhssh4s"><a href="http://www.sb2005.com/news/1746318550.html">一種多功能產床的制作方法</a></div><span>一種多功能產床的制作方法【專利摘要】本實用新型公開了一種多功能產床，涉及婦產科相關醫療設備領域，包括床架、床腿和床面，所述床腿固設于床架的底部，所述床面設于床架上，所述床腿上設有滾輪，所述床面的一頭設有活動床面，所述活動床面連接有液壓桿，所</span></div></li></ul></div></div></div><div id="glidjfkvjou" class="clear"></div></div></div></div><div id="glidjfkvjou" class="footWrap"><div id="glidjfkvjou" class="footer"><div id="glidjfkvjou" class="fnav"></div><div id="glidjfkvjou" class="zuixiamm"><div id="glidjfkvjou" class="f_pic fl"><img src="http://www.sb2005.com/news/view/template/css/img/wx.jpg" alt="油壓機,油壓機廠家" title="油壓機油壓機廠家" /></div><div id="glidjfkvjou" class="f_wz fl"> 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